Nulexin® Comprehensive Analysis

Nulexin^®: A Modern Solution for Bags, Puffiness and Dark Circles Around the Eyes

~Dr. Daniel B. Mowrey, Ph.D.

Puffiness or bagging of the skin under the eyes, together with rings, wrinkles and discoloration (dark circles) under the eye, present a serious cosmetic problem for a great portion of the population. Worse, these are some of the toughest problems to eliminate. There are good reasons for this. The tissues around the eye are very thin, sometimes just a few cells thick. The capillaries that supply blood to this area are among the most fragile and easily disrupted in the entire body and are therefore readily bruised and affected by aging. Dark circles under the eye are due to the accumulation of hemoglobin and its pigmented degradation products-biliverdin, bilirubin and iron-in the dermis and epidermis. Removal of these waste materials from this area is also extremely limited. Hence, as we age, the overall ability of the body to maintain the integrity of the tissues, i.e. the blood supply and the lymphatic system around the eyes, becomes increasingly compromised.

To date there has been precious little one could do about this unsightly problem. Now, innovative research has brought new options to those seeking solutions to these problems. New skin-care products based on this research help restore tone and youthful appearance to this particularly fragile zone around the eye.

Nulexin^® (Generix Laboratories^™ ) includes several revolutionary, functional ingredients specifically designed and scientifically shown to help improve the appearance of the tissues around the eye by targeting factors that create the dark circles, puffiness and baggy appearance.

One of these ingredients, hesperidin methyl chalcone, decreases capillary permeability. That is, it decreases the tendency of disrupted capillaries to leak fluid and hemoglobin out of the small blood vessels into the spaces between cells. These pigmented molecules are what lend a dark-colored appearance to the skin.

Another ingredient, dipeptide valyl-tryptophane (VW) improves lymphatic circulation. One of the functions of the body's lymphatic system is removal of unwanted materials from the tissues surrounding the blood vessels. If capillary permeability increases and lymphatic drainage decreases in the lax tissue around the eyes, then pigmented materials tend to concentrate and find little or no avenue for escape.

A third ingredient, Lipopeptide Pal-GQPR, improves firmness and elasticity and decreases inflammation. Firming up the tissues around the eye helps to decrease puffiness, and decreasing inflammation tends to reduce the redness and soreness that often accompany other unwanted disruptions of the health of these tissues. Often, inflammation is caused by nothing more than ultraviolet radiation (exposure to the sun).

A clinical test of the materials listed above was conducted in 20 female volunteers age 40-60, with chronic puffiness under the eyes. Application of a gel containing 3% of a mixture of those ingredients twice a day for 56 days resulted in a significant reduction in the thickness of swollen periorbital tissue. By day 56, fully 70% of the volunteers experienced a reduction in periorbital edema. A majority of the volunteers reported a smoothing of the eye contour, a reduction in swelling, and a decongestant effect.

As anyone who has experienced puffiness around the eyes knows, results of this kind are truly remarkable.

Another ingredient in Nulexin is a combination of two so-called matrikines, Pal-GHK and Pal-GQPR, with hydroxy-succinimide (NHS) and the flavonoid chrysin.

Testing has shown that Pal-GHK and Pal- GQPR help to reinforce firmness and tone up the skin around the eye. They also facilitate the elimination of pigments responsible for dark circle formation, as well as reduce local inflammation by inhibiting prostaglandins to about the same degree as is obtained with aspirin.

Expanding on what was mentioned above; dark circles under the eye are due to the accumulation of hemoglobin and its pigmented degradation products (biliverdin, bilirubin and iron) in the dermis and epidermis. Laboratory tests have proven that chrysin stimulates a form of the enzyme UGT, leading to the clearance of bilirubin, a yellow pigment molecule. NHS solubilizes this pigment, allowing it to be eliminated.

In a clinical trial, 22 female volunteers applied a gel containing 2% of the mixture just described to the contour of one eye, and a placebo cream to the contour of the other eye, for a period of 56 days. Using sophisticated image analysis, it was determined that the violaceous colors of dark circles under the treated eye were decreased significantly in 60% and 70% of the subjects, respectively. In the responders, the average decrease was almost 20%. Hence, the daily application of this mixture achieves a remarkable improvement in the appearance of dark circles under the eyes.

In summary, Nulexin? contains the most advanced and effective compounds known to help reduce the appearance of bags, puffiness, dark circles, inflammation and soreness that are commonly found around the eyes. Daily application of Nulexin for just a few weeks will help repair years worth of damage done to blood vessels and capillaries, greatly reducing permeability and fragility. It will also have a significant effect on stubborn lymphatic congestion, providing the means for proper drainage of pigments and other waste materials that have accumulated over the years in those delicate tissues around the eyes. Nulexin is a proven solution to some of the most stubborn and resistant cosmetic tribulations of aging.

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